SARS-CoV-2 epitopes – Communicable Diseases Research

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19

코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 진단, 치료법,

Observations and Perspectives on Adaptive Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 적응 면역에 대한 관찰 및 전망

Article

Published on 2022-08-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat
[Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved coronavirus coronavirus 2 cross-reactive develop Epitopes help humoral immune immune memory immune response memory natural infection observation pandemic Pandemics Pathogenesis Perspective pre-existing cross-reactive promote PROTECT public health recognize respiratory SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells Scientific community severe acute respiratory syndrome Coronavirus severe disease T cell T cells T-cell Response T-cell responses Transmission vaccination Vaccine variants variants of concern variants. virus
[DOI] 10.1093/cid/ciac310 PMC 바로가기 [Article Type] Article

SARS-CoV-2 epitope-specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability

COVID-19 질병 중증도 및 항체 내구성 전반에 걸친 SARS-CoV-2 에피토프 특이적 CD4 + 기억 T 세포 반응

Article

Published on 2022-07-222022-09-11
Journal: Science Immunology
[Category] COVID19(2023년), SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive anti-S antibody antibody Antibody Response Antibody responses Boston CD4 Cell cells circulating conducted controls convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity demonstrated disease disease control disease course early disease epitope Epitopes First wave follicular function functions greater histocompatibility complex Hospitalization Immunity individual longitudinal study major histocompatibility complex memory memory T nucleocapsid pandemic peptide Population predict proportion recognizing response SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted severe acute respiratory syndrome Coronavirus subset sustained T cell T cells T cells response T helper USA viral clearance virus
[DOI] 10.1126/sciimmunol.abl9464 PMC 바로가기 [Article Type] Article

SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection

일반적인 TCRαβ 모티프를 가진 SARS-CoV-2-특이 T 세포 기억은 감염 후 혈청 전환되는 예방접종을 받지 않은 어린이에서 확립됩니다

Article

Published on 2022-07-122022-09-11
Journal: Immunity
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults analyzed B cells CD4 CD4(+) T cells CD8 CD8(+) T cells Cell children circulating clonal expansion comparable convalescent coronavirus COVID-19 Epitopes Ex vivo HLA class I Infection memory memory T memory T cell memory T cells motif ORF1a phenotype presenting recruited reduced respiratory response SARS-CoV-2 SARS-CoV-2 epitopes seroconvert seroconverted Seven severe acute respiratory syndrome Coronavirus stem cell T cell T cell memory T cell receptor T cells TCR sequencing tetramer tetramer-specific. to define vaccination virus
[DOI] 10.1016/j.immuni.2022.06.003 PMC 바로가기 [Article Type] Article

COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteins

COVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다

Article

Published on 2022-07-052022-09-11
Journal: Cell Reports
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccination. vaccine response vaccine-induced antibody response widespread
[DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article

Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients

혈액 투석 환자에서 세 번째 BNT162b2 백신 접종 전후의 B.1.617.2(델타) 변이체에 대한 중화 항체 활성

Article

Published on 2022-03-042022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 변종, 진단,

[키워드] activity addition Against Anti-RBD antibodies Anti-RBD antibody B.1.617.2 BNT162b2 correlation COVID-19 COVID-19 vaccination delta variant demonstrated determined by dialysis Epitopes Hemodialysis high risk Humoral immunity IgG IgG antibodies IgG antibody Immune escape Immunity immunocompromised individuals IQR Live virus median neutralization Neutralizing Neutralizing activity Patient SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes second vaccination seroconversion rate seroconverted Seropositivity severe COVID-19 significantly higher the strongest vaccination vaccine dose variant variants variants of concern variants of concern. was performed
[DOI] 10.3389/fimmu.2022.840136 PMC 바로가기 [Article Type] Article

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포

Research Article

Published on 2021-12-292022-09-10
Journal: PLoS Pathogens
[Category] SARS, 치료기술, 치료법,

[키워드] Activation allele Amino acid amino acid sequence Amino acid sequences analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population
[DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article

Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

MIS-A 사례에서 SARS-CoV-2-특이적 T-세포 매개 심근염의 증거

Case Reports

Published on 2021-12-092022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 진단, 치료기술, 치료제,

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별

Article

Published on 2021-12-062022-09-11
Journal: The Journal of Experimental Medicine
[Category] MERS, SARS, 변종, 진단,

Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs

면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별

420

Published on 2021-11-012022-09-10
Journal: Proceedings of the National Academy of Sciences of
[Category] MERS, SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants
[DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420